Description

Cytarabine-D2 CAS NO 40632-26-6 is a deuterated analog of the vital chemotherapeutic agent Cytarabine, where two hydrogen atoms are replaced with stable deuterium isotopes. This strategic isotopic labeling is crucial for advanced pharmacokinetic and metabolic studies, providing enhanced analytical precision and stability. It is an essential research material for pharmaceutical developers, clinical researchers, and analytical laboratories focused on oncology drug development, metabolism research, and the creation of internal standards for mass spectrometry.

Application

• Pharmacokinetic & Metabolic Studies: Used as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS analyses for accurate quantification of Cytarabine in biological matrices.
• Drug Metabolism Research (DMPK): Facilitates the detailed tracing of metabolic pathways and the identification of metabolites in preclinical and clinical research.
• Pharmaceutical R&D: Serves as a critical reference material in the development and validation of analytical methods for new Cytarabine formulations or generics.
• Clinical Research: Enables precise therapeutic drug monitoring (TDM) and bioavailability studies in patient trials.
• Isotope Dilution Mass Spectrometry (IDMS): Provides high-accuracy results for compliance testing and quality control in pharmaceutical manufacturing.
• Biochemical Research: A tool for investigating the mechanism of action and cellular uptake of nucleoside analogs.

Basic Information

Product Name	Cytarabine-D2
CAS No.	40632-26-6
Molecular Formula	C9H11D2N3O5
Molecular Weight	245.22 g/mol
Synonyms	1-β-D-Arabinofuranosyl-4-amino-2(1H)-pyrimidinone-d2; Ara-C-d2; Cytosine Arabinoside-d2; 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone-d2; Cytosar-U-d2 (labeled analog); [2H2]-Cytarabine; Deuterated Cytarabine
EINECS	Contact for details

Quality Control

Every batch of Cytarabine-D2 is manufactured and analyzed under strict quality management systems to ensure the highest standards of isotopic purity and chemical identity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA), detailing isotopic enrichment (D%), chemical purity, and analytical results, is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere if specified and stored in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.