Description

2'-Deoxyuridine-5,6-D2 is a deuterium-labeled analog of the nucleoside deoxyuridine, specifically deuterated at the 5 and 6 positions of the uracil base. This isotopic labeling makes it an essential tool in advanced research, particularly in mass spectrometry and pharmacokinetic studies, where it serves as a stable internal standard to ensure analytical accuracy and traceability. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and academic sectors for drug metabolism and proteomics research.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard in quantitative bioanalytical methods for measuring deoxyuridine or related metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for tracing metabolic pathways, studying absorption, distribution, metabolism, and excretion (ADME) of nucleoside-based pharmaceuticals.
• Proteomics and Biomarker Research: Employed in stable isotope labeling by amino acids in cell culture (SILAC) and other techniques to quantify protein expression and discover biomarkers.
• Nucleic Acid Research: Serves as a building block or tracer in studies investigating DNA synthesis, repair mechanisms, and the role of thymidylate synthase.
• Diagnostic Assay Development: Used in the development and calibration of clinical diagnostic kits for conditions related to nucleotide imbalance or metabolic disorders.

Basic Information

Product Name	2'-Deoxyuridine-5,6-D2
CAS No.	40632-23-3
Molecular Formula	C9H10D2N2O5
Molecular Weight	230.21 g/mol
Synonyms	2'-Deoxyuridine-d2; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4(1H,3H)-pyrimidinedione-5,6-d2; Deoxyuridine-5,6-d2; 5,6-Dideutero-2'-deoxyuridine; Uridine, 2'-deoxy-5,6-d2-; dU-d2; Stable Isotope Labeled Deoxyuridine
EINECS	Contact for details

Quality Control

Our 2'-Deoxyuridine-5,6-D2 is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity, isotopic enrichment (D atom %), and absence of biological contaminants. We adhere to relevant standards for research chemicals, ensuring reliability for your most sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccation and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D atom %)	≥ 98.0% (min.)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.