Description

4,4'-Dimethoxytrityl Chloride (CAS NO 40615-36-9) is a highly reactive and versatile tritylating agent essential for the protection of primary hydroxyl groups in synthetic organic chemistry. Its primary value lies in its exceptional selectivity and stability under a wide range of reaction conditions, making it a cornerstone reagent for nucleotide and oligonucleotide synthesis. This compound is critically needed by research institutions, pharmaceutical manufacturers, and CROs/CDMOs specializing in the development of antisense oligonucleotides, siRNA, and other advanced therapeutic nucleic acids.

Application

• Oligonucleotide Synthesis: As a key protecting group reagent for the 5'-hydroxyl function of nucleosides and nucleotides in solid-phase phosphoramidite chemistry.
• Pharmaceutical Intermediates: In the synthesis of active pharmaceutical ingredients (APIs) for nucleic acid-based therapeutics, including antisense drugs and siRNA conjugates.
• Research & Development: For the protection and deprotection strategies in complex carbohydrate, natural product, and peptide synthesis where selective hydroxyl protection is required.
• Diagnostic Probe Manufacturing: Used in the production of labeled DNA and RNA probes for diagnostic assays and genomic research.
• Scale-up & Process Chemistry: Employed in the kilogram-scale production of protected nucleoside building blocks for commercial therapeutic manufacturing.
• Bioconjugation Chemistry: Facilitates the site-specific modification of biomolecules by introducing a protected handle for subsequent functionalization.

Basic Information

Product Name	4,4'-Dimethoxytrityl Chloride
CAS No.	40615-36-9
Molecular Formula	C21H19ClO2
Molecular Weight	338.83 g/mol
Synonyms	DMTr-Cl; 4,4'-Dimethoxytriphenylmethyl Chloride; p-Anisylchlorodiphenylmethane; Monomethoxytrityl Chloride (common historical name); Chloro-bis(4-methoxyphenyl)phenylmethane; 1-Chloro-1,1-bis(4-methoxyphenyl)ethane (incorrect but sometimes used); DMT-Cl; MMTrCl
EINECS	Contact for details

Quality Control

Our 4,4'-Dimethoxytrityl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to relevant industry guidelines to support our customers' needs in research, GMP, and commercial production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in dichloromethane, acetonitrile, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.