Description

4,4'-Dimethoxytrityl Alcohol is a key protected alcohol derivative and a vital intermediate in organic synthesis. Its primary value lies in its role as a precursor for the dimethoxytrityl (DMT) protecting group, which is essential for the controlled synthesis of complex molecules. This compound is critically needed by manufacturers in the pharmaceutical and nucleoside/nucleotide industries, particularly for oligonucleotide and peptide synthesis.

Application

• Oligonucleotide Synthesis: Serves as the precursor for the 4,4'-Dimethoxytrityl (DMT) chloride reagent, used for the 5'-OH protection of nucleosides in solid-phase phosphoramidite chemistry.
• Peptide Synthesis: Employed in the preparation of specialized protecting groups for amino acids during complex peptide assembly.
• Pharmaceutical Intermediates: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals requiring selective hydroxyl protection.
• Chemical Research & Development: Used in academic and industrial R&D labs for developing new synthetic methodologies and protecting group strategies.
• Diagnostic Reagents: Finds application in the manufacture of probes and other molecular biology reagents where temporary protection is required.

Basic Information

Product Name	4,4'-Dimethoxytrityl Alcohol
CAS No.	40615-35-8
Molecular Formula	C21H20O3
Molecular Weight	320.38 g/mol
Synonyms	Bis(4-methoxyphenyl)phenylmethanol; DMT Alcohol; 4,4'-Dimethoxytriphenylmethanol; (4-Methoxyphenyl)bis(4-methoxyphenyl)methanol; α,α-Bis(4-methoxyphenyl)benzenemethanol; 1,1-Bis(4-methoxyphenyl)-1-phenylmethanol; DMTr-OH
EINECS	Contact for details

Quality Control

Our 4,4'-Dimethoxytrityl Alcohol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.