Description

(1R,4S)-1,4-Dichlorocyclooctane is a high-purity, stereochemically defined chlorinated cyclooctane derivative, serving as a valuable chiral building block and intermediate in advanced organic synthesis. Its defined stereochemistry and reactive chlorinated sites make it a critical precursor for constructing complex molecular architectures with precise spatial orientation. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used as a precursor in the manufacture of advanced pesticides and herbicides, where its stereochemistry can influence biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a backbone for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis to induce enantioselectivity.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for producing specialty polymers with unique thermal or mechanical properties.
• Organic Synthesis Research: A versatile reagent in academic and industrial R&D for ring-opening reactions, nucleophilic substitutions, and cyclization studies.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing complex, stereospecific odorants and flavor compounds.

Basic Information

Product Name	(1R,4S)-1,4-Dichlorocyclooctane
CAS No.	40572-74-5
Molecular Formula	C8H14Cl2
Molecular Weight	181.10 g/mol
Synonyms	(1R,4S)-1,4-Dichlorocyclooctane; (1R-cis)-1,4-Dichlorocyclooctane; 1,4-Dichlorocyclooctane, (1R,4S)-rel-; 1,4-Dichlorocyclooctane (stereoisomer); Cyclooctane, 1,4-dichloro-, (1R,4S)-; (1R,4S)-rel-1,4-Dichlorocyclooctane; cis-1,4-Dichlorocyclooctane (enantiomer)
EINECS	Contact for details

Quality Control

Our (1R,4S)-1,4-Dichlorocyclooctane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC and GC, to ensure high enantiomeric excess (ee) and chemical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. Handle and store under an inert atmosphere if prolonged storage is required to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.