Description

4-Maleimidobenzoic Acid Methyl Ester is a high-purity bifunctional linker molecule containing both a maleimide and an activated ester group. This compound is critical for creating stable covalent bonds in bioconjugation and materials science, enabling the precise cross-linking of thiol-containing molecules like peptides or proteins to amine-containing surfaces or polymers. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotech, and advanced materials industries for developing drug conjugates, diagnostic assays, and functionalized polymers.

Application

• Bioconjugation Reagent: For site-specific coupling of thiolated biomolecules (e.g., antibodies, peptides) to amine-functionalized carriers, nanoparticles, or surfaces.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key heterobifunctional crosslinker for attaching cytotoxic payloads to monoclonal antibodies via stable thioether bonds.
• Polymer Functionalization: Used to introduce maleimide groups into polymer backbones or dendrimers for subsequent thiol-ene "click" chemistry modifications.
• Surface Immobilization: Enables the covalent attachment of proteins or enzymes onto biosensor chips, microarray slides, or chromatographic resins.
• Diagnostic Reagent Synthesis: Employed in the preparation of enzyme-labeled antibodies or hapten-protein conjugates for immunoassays (ELISA, lateral flow tests).
• Hydrogel Formation: Acts as a cross-linking agent in the synthesis of biocompatible hydrogels for drug delivery or tissue engineering applications.

Basic Information

Product Name	4-Maleimidobenzoic Acid Methyl Ester
CAS No.	40349-49-3
Molecular Formula	C12H9NO4
Molecular Weight	231.20 g/mol
Synonyms	4-(Maleimidomethyl)benzoic Acid Methyl Ester; Methyl 4-(Maleimidomethyl)benzoate; Methyl 4-Maleimidobenzoate; 4-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl Benzoic Acid Methyl Ester; 4-Maleimidomethyl Benzoic Acid Methyl Ester; MBME; Methyl 4-(Maleimidomethyl)benzenecarboxylate; 1-[(4-Methoxycarbonyl)phenylmethyl]maleimide
EINECS	Contact for details

Quality Control

Our 4-Maleimidobenzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is light-sensitive and should be stored away from light. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.