Description

1-((Trimethylsilyl)Ethynyl)-3-Fluorobenzene is a specialized organosilicon building block featuring both a fluorinated aromatic ring and a protected terminal alkyne group. This unique bifunctional structure makes it a high-value intermediate for constructing complex molecular architectures in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for applications in medicinal chemistry, material science, and the synthesis of novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated aromatic and alkyne motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides requiring specific fluorine-substituted structures.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of advanced polymers, resins, and specialty materials.
• Organic Synthesis Reagent: Employed in Sonogashira coupling and other palladium-catalyzed reactions to create complex conjugated systems.
• Ligand and Catalyst Development: Useful for synthesizing novel ligands and organometallic catalysts used in asymmetric synthesis.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research exploring the effects of fluorine substitution on molecular properties.

Basic Information

Product Name	1-((Trimethylsilyl)Ethynyl)-3-Fluorobenzene
CAS No.	40230-96-4
Molecular Formula	C11H13FSi
Molecular Weight	192.30 g/mol
Synonyms	3-Fluoro-1-((trimethylsilyl)ethynyl)benzene; 1-Ethynyl-3-fluorobenzene trimethylsilyl ether; 3-Fluorophenyl(trimethylsilyl)acetylene; m-Fluorophenyl(trimethylsilyl)acetylene; TMS-3-Fluorophenylacetylene; (3-Fluorophenyl)ethynyltrimethylsilane; 40230-96-4; 1-((Trimethylsilyl)ethynyl)-3-fluorobenzene
EINECS	Contact for details

Quality Control

Our production of 1-((Trimethylsilyl)Ethynyl)-3-Fluorobenzene adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.