Description

3-[(Trimethylsilyl)Ethynyl]Toluene is a specialized organosilicon building block featuring a trimethylsilyl-protected alkyne group attached to a toluene core. This compound matters for its role as a versatile intermediate in advanced organic synthesis, particularly in cross-coupling reactions and the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, especially those requiring alkyne functionalization for click chemistry or further derivatization.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the protected alkyne allows for selective coupling reactions.
• Material Science & Polymer Chemistry: Serves as a monomer or functionalizing agent in the production of specialty polymers, dendrimers, and silicon-containing advanced materials.
• Organic Electronics: Employed in the synthesis of conjugated molecules and molecular wires for applications in OLEDs and organic semiconductors.
• Cross-Coupling Reactions: An essential substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Ligand & Catalyst Development: Used to create novel ligands and organometallic complexes for catalytic applications.
• Chemical Research: A valuable reagent in academic and industrial laboratories for methodology development and exploring new synthetic pathways.

Basic Information

Product Name	3-[(Trimethylsilyl)Ethynyl]Toluene
CAS No.	40230-90-8
Molecular Formula	C12H16Si
Molecular Weight	188.34 g/mol
Synonyms	3-(Trimethylsilylethynyl)toluene; 1-Methyl-3-[(trimethylsilyl)ethynyl]benzene; m-(Trimethylsilylethynyl)toluene; Toluene, 3-[(trimethylsilyl)ethynyl]-; 3-Ethynyltoluene trimethylsilyl ether; 3-(Trimethylsilyl)ethynyltoluene; m-Tolyl(trimethylsilyl)acetylene
EINECS	Contact for details

Quality Control

Our 3-[(Trimethylsilyl)Ethynyl]Toluene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment. We are committed to meeting the stringent requirements of research and cGMP environments where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.