Description

Methyl Bromoacetate, [2-14C] is a carbon-14 labeled isotopologue of methyl bromoacetate, a versatile alkylating agent and key synthetic intermediate. This radiolabeled compound is essential for conducting precise metabolic and pharmacokinetic studies, enabling researchers to track molecular pathways with high specificity. It is primarily utilized by pharmaceutical, agrochemical, and academic research institutions engaged in drug discovery, environmental fate studies, and the synthesis of complex labeled molecules.

Application

• Tracer Studies in Drug Metabolism and Pharmacokinetics (DMPK): Used as a building block to synthesize carbon-14 labeled drug candidates for absorption, distribution, metabolism, and excretion (ADME) studies.
• Agrochemical Research: Employed in the synthesis of radiolabeled pesticides or herbicides to study their environmental degradation, plant uptake, and residue analysis.
• Bioconjugation and Probe Synthesis: Serves as an alkylating agent for introducing a radiolabeled tag onto biomolecules (e.g., peptides, proteins) for imaging or binding assays.
• Organic Synthesis Intermediate: A key precursor for the preparation of various carbon-14 labeled compounds, including α-amino acids, heterocycles, and complex natural product analogs.
• Mechanistic Biochemical Studies: Facilitates the investigation of enzymatic reaction mechanisms where the transfer of a one-carbon unit or specific bond cleavage is tracked.

Basic Information

Product Name	Methyl Bromoacetate, [2-14C]
CAS No.	40145-36-6
Molecular Formula	C3H514COOCH3Br
Molecular Weight	Contact for details
Synonyms	Methyl 2-bromo[2-14C]acetate; [2-14C]-Methyl bromoacetate; Bromoacetic-2-14C acid methyl ester; Methyl (bromo-2-14C)acetate; Carbon-14 labeled methyl bromoacetate; Methyl α-bromo[2-14C]acetate; Radiolabeled methyl bromoacetate
EINECS	Contact for details

Quality Control

Every batch of our Methyl Bromoacetate, [2-14C] is manufactured and analyzed under strict quality systems to ensure high chemical and radiochemical purity, specific activity, and isotopic enrichment. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing all analytical parameters, including HPLC, NMR, and radiometric purity, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area, away from strong acids and organic solvents. For long-term stability, storage at recommended low temperatures (e.g., -20°C) is advised. Please refer to the specific Material Safety Data Sheet (MSDS) for detailed handling and storage instructions.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR/NMR)	Conforms to structure
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity	≥ 97%
Specific Activity	Contact for details
Solvent (if supplied as solution)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.