Description

Ethyl Bromoacetate, [1,2-14C] is a carbon-14 labeled isotopologue of ethyl bromoacetate, a versatile alkylating agent and synthetic intermediate. This radiolabeled compound is essential for precise metabolic and pharmacokinetic studies, enabling researchers to trace the fate of molecules in complex biological systems. It is a critical tool for scientists in pharmaceutical R&D, agrochemical development, and advanced organic synthesis who require high-specific-activity materials for autoradiography, ADME (Absorption, Distribution, Metabolism, Excretion) studies, and mechanistic pathway elucidation.

Application

• Tracer Studies in Pharmaceutical Research: Used as a radiolabeled precursor or intermediate in the synthesis of 14C-labeled drug candidates for definitive ADME and mass balance studies.
• Metabolic Pathway Analysis: Enables the detailed tracking of biochemical pathways in plants, animals, and microorganisms in agrochemical and biochemical research.
• Organic Synthesis Building Block: Serves as a labeled alkylating agent for introducing the -CH2CO2Et moiety with a radioactive tag into target molecules for further analysis.
• Autoradiography and Imaging: Provides the radioactive source for techniques used to visualize the distribution of compounds in tissues, cells, or on chromatographic plates.
• Environmental Fate Studies: Applied in research to monitor the degradation, transformation, and binding of chemical compounds in environmental matrices.
• Mechanistic Reaction Studies: Utilized to investigate reaction mechanisms in organic chemistry by tracing the incorporation of the labeled carbon atoms.

Basic Information

Product Name	Ethyl Bromoacetate, [1,2-14C]
CAS No.	40145-35-5
Molecular Formula	C4H714CO2Br *or* C4H7BrO2 (with 14C at positions 1 & 2)
Molecular Weight	~167.00 g/mol (for unlabeled); Specific activity provided on CoA.
Synonyms	Bromoacetic-1,2-14C acid ethyl ester; Ethyl 2-bromoacetate-1,2-14C; [1,2-14C]Ethyl bromoacetate; 14C-Ethyl bromoacetate; Bromoacetic acid ethyl ester-1,2-14C; Ethyl α-bromoacetate-1,2-14C; Ethyl bromoethanoate-1,2-14C
EINECS	Contact for details

Quality Control

Every batch of Ethyl Bromoacetate, [1,2-14C] is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards for radiolabeled compounds. Certificates of Analysis (COA) detailing specific activity, radiochemical purity, chemical purity, and analytical methods (e.g., HPLC, radio-HPLC) are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) in a dedicated, appropriately shielded facility for radioactive materials. This product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere if specified. Handle and store in accordance with all local, national, and international regulations governing radioactive substances.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR / NMR)	Conforms to structure
Specific Activity	As per customer requirement (mCi/mmol)
Radiochemical Purity (Radiometric HPLC)	≥ 98%
Chemical Purity (HPLC / GC)	≥ 95%
Solvent (if supplied in solution)	Specified on CoA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.