Description

Glycine-D5 is a stable isotope-labeled analog of the fundamental amino acid glycine, where five hydrogen atoms are replaced by deuterium. This high-purity compound is essential for advanced analytical techniques, providing an internal standard for precise quantification and metabolic pathway tracing. It is a critical reagent for researchers and manufacturers in pharmaceutical development, clinical diagnostics, and metabolic research requiring exceptional accuracy and reliability.

Application

• Mass Spectrometry Internal Standard: Serves as a critical quantitative reference standard in LC-MS and GC-MS analysis of glycine and related metabolites in biological matrices.
• Metabolic Research & Tracing: Used in stable isotope labeling studies to investigate amino acid metabolism, protein synthesis rates, and biochemical pathways in vivo and in vitro.
• Pharmaceutical R&D: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug molecules and their metabolites.
• Clinical Diagnostics: Utilized in developing and calibrating assays for accurate measurement of glycine levels in clinical samples, aiding in the diagnosis of metabolic disorders.
• NMR Spectroscopy: Acts as a deuterated solvent or a probe in nuclear magnetic resonance studies due to its isotopic purity.
• Biochemical Reagent: Used in the synthesis of deuterated peptides, proteins, and other complex molecules for specialized research applications.

Basic Information

Product Name	Glycine-D5
CAS No.	4896-77-9
Molecular Formula	C₂D₅NO₂
Molecular Weight	80.10 g/mol
Synonyms	Glycine-2,2-d2,d3; Aminoacetic acid-D5; Deuterated glycine; Glycine-d5; (2H5)Glycine; Amino-D3-acetic-2,2-d2 acid; NSC 760105; Glycine (amino-D3, 2,2-d2)
EINECS	Contact for details

Quality Control

Every batch of Glycine-D5 is manufactured and tested under strict quality management systems. We guarantee high isotopic and chemical purity, with comprehensive testing including NMR, MS, and HPLC analysis to confirm identity, isotopic enrichment, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring full traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.