Description

Glycine-2,2-D2 is a stable isotope-labeled analog of the fundamental amino acid glycine, where two hydrogen atoms at the 2-position are replaced with deuterium (D). This subtle modification makes it an invaluable internal standard and tracer in advanced analytical and metabolic research. It is essential for scientists and manufacturers requiring precise quantification and pathway analysis in complex biological matrices. Key industries that utilize this specialty chemical include pharmaceutical research, analytical laboratories, and the development of diagnostic agents.

Application

• Internal Standard for Mass Spectrometry (MS): Critical for accurate quantification of glycine and related metabolites in LC-MS and GC-MS analyses, ensuring data reliability in bioanalytical studies.
• Metabolic Pathway Tracing: Used in NMR and MS-based studies to track and elucidate biochemical pathways, drug metabolism, and protein synthesis mechanisms.
• Pharmaceutical Research & Development: Employed in the development and validation of assays for new drug candidates, pharmacokinetics, and biomarker discovery.
• Proteomics and Stable Isotope Labeling: A key component in SILAC (Stable Isotope Labeling by Amino acids in Cell culture) and other proteomic techniques for comparative protein expression analysis.
• Diagnostic Reagent Manufacturing: Serves as a raw material in formulating calibrated reagents and kits for clinical diagnostics and inborn errors of metabolism testing.
• NMR Spectroscopy Solvent & Reference: Acts as a chemical shift reference or is used in deuterated solvent mixtures for nuclear magnetic resonance spectroscopy.

Basic Information

Product Name	Glycine-2,2-D2
CAS No.	4896-75-7
Molecular Formula	C₂H₂D₂NO₂
Molecular Weight	77.07 g/mol
Synonyms	Glycine-d2; Deuterated Glycine; Aminoacetic-2,2-d2 acid; (2,2-Dideuterio)glycine; Glycine (amino-d2); NSC 112495; Glycine-2,2-dideutero; Aminoacetic acid-d2
EINECS	Contact for details

Quality Control

Every batch of our Glycine-2,2-D2 is produced and tested under stringent quality management systems to ensure exceptional isotopic and chemical purity for research-critical applications. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as isotopic enrichment (D atom %), chemical purity, and impurity profiles. Our quality commitment aligns with the rigorous standards expected in pharmaceutical and analytical markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D atom %)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.