Description

5,6,8,14-Tetradehydro-6-Methoxy-17-Methyl-2,3-[Methylenebisoxy]Morphinan-7β-Ol is a complex morphinan derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis and analytical characterization of specialized active pharmaceutical ingredients (APIs). It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthetic pathways for complex opioid or morphinan-based active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for method development, validation, and quality control (QC) testing in HPLC, GC-MS, or NMR analyses within pharmaceutical laboratories.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies aimed at discovering new compounds with targeted pharmacological profiles.
• Process Chemistry Development: Employed in optimizing synthetic routes and scaling up production processes for related pharmaceutical compounds.
• Academic Research: Utilized in university and institutional labs for studies in organic synthesis, pharmacology, and neurochemistry.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations specializing in the production of high-potency APIs (HPAPIs) and controlled substances.

Basic Information

Item	Details
Product Name	5,6,8,14-Tetradehydro-6-Methoxy-17-Methyl-2,3-[Methylenebisoxy]Morphinan-7β-Ol
CAS No.	4850-04-8
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	7,8-Didehydro-4,5α-epoxy-6-methoxy-17-methylmorphinan-3,14-diol 3,14-Diacetate (ester); 3,14-Diacetyloxy-7,8-didehydro-4,5α-epoxy-6-methoxy-17-methylmorphinan; 3,14-Diacetoxy-7,8-didehydro-4,5α-epoxy-6-methoxy-17-methylmorphinan; 6-Methoxy-17-methyl-2,3-[methylenebis(oxy)]morphinan-7β-ol, 5,6,8,14-tetradehydro-; Thebacon Impurity; Dihydrocodeinone Enol Acetate; Acedicon; Acedicone
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and spectroscopic identification (IR, NMR), to ensure it meets precise customer specifications. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.