Description

14-Hydroxycodeine is a semi-synthetic opioid derivative of codeine, distinguished by the introduction of a hydroxyl group at the 14-position. This structural modification is of significant interest in pharmaceutical research for exploring new analgesic pathways and metabolic profiles. It serves as a critical intermediate and reference standard in the development and quality control of opioid-based medications. Key industries that utilize this compound include pharmaceutical R&D, analytical laboratories, and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of novel opioid analgesics and antitussives.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical testing.
• Metabolic Studies: Employed in preclinical research to study the metabolism and pharmacokinetics of codeine derivatives.
• Medicinal Chemistry Research: A key compound for structure-activity relationship (SAR) studies to develop new central nervous system (CNS) agents.
• Analytical Testing: Used in forensic and clinical toxicology laboratories for identification and quantification purposes.

Basic Information

Product Name	14-Hydroxycodeine
CAS No.	4829-46-3
Molecular Formula	C18H21NO4
Molecular Weight	315.36 g/mol
Synonyms	14-Hydroxycodeine; 7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α,14-diol; 14-Hydroxycodeine base; 14-OH-Codeine; O3-Methyl-14-hydroxy-morphine
EINECS	Contact for details

Quality Control

Our 14-Hydroxycodeine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all test results are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.