Description

Pregna-1,4-Diene-3,20-Dione, 21-(Acetyloxy)-9-Chloro-11,17-Dihydroxy-16-Methyl-, (11β,16β)- is a high-purity synthetic corticosteroid derivative, also known as Clocortolone Pivalate. This compound is valued for its potent anti-inflammatory and immunosuppressive properties, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily required by pharmaceutical R&D laboratories and manufacturers for the development and production of topical corticosteroid medications targeting dermatological conditions.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key synthetic precursor in the manufacture of corticosteroid drugs, specifically Clocortolone Pivalate.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to develop new topical anti-inflammatory formulations.
• Dermatological Preparations: Serves as a core component in the synthesis of creams, ointments, and lotions for treating eczema, psoriasis, and dermatitis.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling production from laboratory to commercial batch sizes.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation (HPLC, GC).
• Custom Synthesis: Basis for the synthesis of novel steroid analogs with modified pharmacological profiles for specialized therapeutic applications.

Basic Information

Item	Detail
Product Name	Pregna-1,4-Diene-3,20-Dione, 21-(Acetyloxy)-9-Chloro-11,17-Dihydroxy-16-Methyl-, (11β,16β)-
CAS No.	4735-64-2
Molecular Formula	C₂₆H₃₃ClO₇
Molecular Weight	493.00 g/mol
Synonyms	Clocortolone Pivalate; 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate; 9-Chloro-11β,17-dihydroxy-16β-methyl-21-(acetyloxy)-pregna-1,4-diene-3,20-dione; NSC 101791; Clocortolone 21-acetate; 11β,16β-9-Chloro-11,17-dihydroxy-16-methyl-21-(acetyloxy)-pregna-1,4-diene-3,20-dione
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione, 21-(Acetyloxy)-9-Chloro-11,17-Dihydroxy-16-Methyl-, (11β,16β)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.