Description

Indolo2,3-Aquinolizine-2-Acetic Acid, 3-Ethenyl-1,2,3,4,6,7,12,12B-Octahydro-8-Methoxy-.Alpha.-(Methoxymethylene)-, Methyl Ester, (.Alpha.E,2S,3R,12Bs)- is a complex, stereochemically defined alkaloid derivative with significant synthetic utility. This compound serves as a critical chiral building block and advanced intermediate in the synthesis of complex natural products and pharmacologically active molecules. It is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of indole alkaloid-based drug candidates targeting neurological and oncological pathways.
• Asymmetric Synthesis: Utilized as a sophisticated building block for constructing complex molecular architectures with defined stereochemistry in medicinal chemistry.
• Natural Product Synthesis: Serves as a core structural unit for the total or semi-synthesis of complex natural products belonging to the indoloquinolizidine family.
• Chemical Biology Research: Used in the development of molecular probes and tool compounds to study biological mechanisms and enzyme interactions.
• Process Chemistry Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) requiring this specific stereochemical framework.
• Academic Research: A valuable compound for university and institutional research in organic chemistry, catalysis, and new synthetic methodology development.

Basic Information

Item	Details
Product Name	Indolo2,3-Aquinolizine-2-Acetic Acid, 3-Ethenyl-1,2,3,4,6,7,12,12B-Octahydro-8-Methoxy-.Alpha.-(Methoxymethylene)-, Methyl Ester, (.Alpha.E,2S,3R,12Bs)-
CAS No.	4697-66-9
Molecular Formula	C22H27NO4
Molecular Weight	369.46 g/mol
Synonyms	(αE,2S,3R,12bS)-3-Ethenyl-1,2,3,4,6,7,12,12b-Octahydro-8-methoxy-α-(methoxymethylene)indolo[2,3-a]quinolizine-2-acetic Acid Methyl Ester; Methyl (2S,3R,12bS)-3-Ethenyl-1,2,3,4,6,7,12,12b-octahydro-8-methoxy-α-(methoxymethylene)indolo[2,3-a]quinolizine-2-acetate; 3-Vinyl-1,2,3,4,6,7,12,12b-octahydro-8-methoxy-α-(methoxymethylene)indolo[2,3-a]quinolizine-2-acetic Acid Methyl Ester; Indoloquinolizine Derivative; Alkaloid Intermediate CAS 4697-66-9.
EINECS	Contact for details

Quality Control

Our Indolo2,3-Aquinolizine-2-Acetic Acid, 3-Ethenyl-1,2,3,4,6,7,12,12B-Octahydro-8-Methoxy-.Alpha.-(Methoxymethylene)-, Methyl Ester, (.Alpha.E,2S,3R,12Bs)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure consistent identity, purity, and stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.