Description

(R)-6,7-Dimethoxy-3β-[[(5R,6R)-5,6,7,8-Tetrahydro-6-Methyl-1,3-Dioxolo[4,5-G]Isoquinolin]-5-Yl]Isobenzofuran-1(3H)-One is a high-purity, stereochemically defined alkaloid derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel pharmaceutical agents, particularly in the realm of central nervous system (CNS) and cardiovascular research. It is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of potential therapeutic agents targeting neurological and cardiovascular pathways.
• Asymmetric Synthesis: Employed as a sophisticated building block for constructing complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Utilized in university and institutional labs for studying alkaloid chemistry, synthetic methodology, and catalysis.
• Process Chemistry Development: Investigated for scalable synthesis routes in the pilot-scale production of advanced active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	(R)-6,7-Dimethoxy-3β-[[(5R,6R)-5,6,7,8-Tetrahydro-6-Methyl-1,3-Dioxolo[4,5-G]Isoquinolin]-5-Yl]Isobenzofuran-1(3H)-One
CAS No.	4370-85-8
Molecular Formula	C23H25NO6
Molecular Weight	411.45 g/mol
Synonyms	6,7-Dimethoxy-3-[(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)methyl]-1(3H)-isobenzofuranone (R,R)-isomer; (R,R)-Galanthamine precursor; (3R,5R,6R,16aR)-3-Methoxy-16-methyl-11,16,17,18,19,20-hexahydro-4H-3,13-dioxa-8-azabenzo[e]pyrido[4,3-b][1,4]dioxacyclooctadecine-5,14-dione (related structure); Alkaloid derivative intermediate; Lycorine-type alkaloid intermediate.
EINECS	Contact for details

Quality Control

Our (R)-6,7-Dimethoxy-3β-[[(5R,6R)-5,6,7,8-Tetrahydro-6-Methyl-1,3-Dioxolo[4,5-G]Isoquinolin]-5-Yl]Isobenzofuran-1(3H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, NMR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.