Description

Cyclopropyl Bromide CAS NO 4333-56-6 is a versatile and highly reactive alkyl halide building block, essential for constructing the cyclopropane ring system in advanced organic synthesis. Its strained three-membered ring structure makes it a critical intermediate for introducing the cyclopropyl moiety, a key pharmacophore in modern medicinal chemistry. This compound is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing the cyclopropane ring, which is prevalent in drugs targeting CNS disorders, antivirals, and antibiotics.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides where the cyclopropyl group enhances biological activity and stability.
• Material Science Research: Serves as a precursor for creating novel polymers, liquid crystals, and organic electronic materials with unique structural properties.
• Cross-Coupling Reactions: An effective substrate in Negishi, Suzuki, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Nucleophilic Substitution: Employed in SN2 reactions to introduce the cyclopropylmethyl group into various molecular scaffolds.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological mechanisms and enzyme inhibition.

Basic Information

Product Name	Cyclopropyl Bromide
CAS No.	4333-56-6
Molecular Formula	C3H5Br
Molecular Weight	120.98 g/mol
Synonyms	Bromocyclopropane; Cyclopropyl Bromide; Cyclopropane, bromo-; Bromomethyl ethylene; (Bromomethyl)ethylene; Cyclopropanebromide; Bromo-cyclopropane; 1-Bromo-cyclopropane
EINECS	224-390-4

Quality Control

Our Cyclopropyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its light-sensitive nature and classification as a strong acid/organic solvent, ensure containers are kept sealed and in secondary containment.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.50 - 1.55 g/mL
Refractive Index (n20D)	1.480 - 1.490

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.