Description

4-Phenyl-1,2,4-Triazoline-3,5-Dione (PTAD) is a highly reactive heterocyclic compound belonging to the class of triazolinediones. This specialized chemical is valued for its exceptional role as a powerful dienophile and enophile in Diels-Alder and ene reactions, enabling precise chemical synthesis and functionalization. It is a critical reagent for researchers and manufacturers in pharmaceutical development, polymer chemistry, and advanced material science, where it is used for labeling, crosslinking, and synthesizing complex molecular architectures.

Application

• Chemical Synthesis Reagent: A key dienophile for high-yield, stereoselective Diels-Alder cycloaddition reactions in organic and medicinal chemistry.
• Bioconjugation & Protein Labeling: Used for selective modification of amino acids, peptides, and proteins due to its rapid reaction with electron-rich alkenes and dienes.
• Polymer Modification & Crosslinking: Facilitates the functionalization and crosslinking of polymers containing unsaturated bonds to alter material properties.
• Protecting Group Chemistry: Employed in synthetic routes for the temporary protection of functional groups.
• Analytical Chemistry: Acts as a derivatization agent for the analysis of unsaturated compounds via chromatography or mass spectrometry.
• Material Science Research: Utilized in the surface modification of nanomaterials and the creation of novel organic frameworks.

Basic Information

Product Name	4-Phenyl-1,2,4-Triazoline-3,5-Dione
CAS No.	4233-33-4
Molecular Formula	C8H5N3O2
Molecular Weight	175.15 g/mol
Synonyms	PTAD; 1,2,4-Triazoline-3,5-dione, 4-phenyl-; 4-Phenyl-1,2,4-triazole-3,5-dione; 4-Phenylurazole; 4-Phenyl-1,2,4-triazolidine-3,5-dione; Phenyltriazolinedione
EINECS	224-195-9

Quality Control

Our 4-Phenyl-1,2,4-Triazoline-3,5-Dione is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and industrial applications. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term stability. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	205 - 210 °C (dec.)
Loss on Drying	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.