Description

1-(Trimethylacetyl)Imidazole is a versatile and highly reactive chemical building block, primarily used as an acylating agent and a key intermediate in organic synthesis. Its value lies in its ability to facilitate the efficient introduction of the pivaloyl (trimethylacetyl) group, a bulky moiety that can impart significant stability and alter the physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is employed in the development of active ingredients, catalysts, and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring pivaloyl-protected functional groups.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and pesticides where the pivaloyl group enhances compound stability and bioavailability.
• Peptide Chemistry: Serves as a coupling reagent or protecting group agent in the synthesis of peptides and modified amino acids.
• Polymer Science: Intermediate for creating specialized polymers, coatings, and resins with tailored thermal and chemical resistance properties.
• Catalyst and Ligand Preparation: Employed in the synthesis of N-heterocyclic carbene (NHC) precursors and other organocatalysts.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating novel molecular architectures.

Basic Information

Product Name	1-(Trimethylacetyl)Imidazole
CAS No.	4195-19-1
Molecular Formula	C8H12N2O
Molecular Weight	152.20 g/mol
Synonyms	Pivaloyl Imidazole; 1-Pivaloylimidazole; 1-(2,2-Dimethylpropanoyl)imidazole; 1-(2,2-Dimethylpropionyl)imidazole; 1H-Imidazole, 1-(2,2-dimethyl-1-oxopropyl)-; Trimethylacetyl Imidazole; N-Pivaloylimidazole; N-(2,2-Dimethylpropionyl)imidazole
EINECS	224-086-2

Quality Control

Our 1-(Trimethylacetyl)Imidazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for use in GMP-compliant pharmaceutical synthesis and other critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.