Description

n-tert-Butylmaleimide (CAS NO 4144-22-3) is a versatile and highly reactive maleimide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its role as a dienophile in Diels-Alder reactions and as a Michael acceptor, enabling the creation of complex, functionalized molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and polymer industries, particularly for developing active pharmaceutical ingredients (APIs), specialty polymers, and performance materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs) via cycloaddition and conjugation reactions.
• Polymer Science & Material Modification: Used as a cross-linking agent and comonomer in the production of specialty polymers, resins, and functional materials to enhance thermal stability and mechanical properties.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and other crop protection agents.
• Bioconjugation & Protein Labeling: Utilized for modifying proteins, antibodies, and peptides due to its selective reactivity with thiol groups, important for diagnostics and biotherapeutics.
• Organic Synthesis & Research: A valuable dienophile in Diels-Alder reactions for constructing complex heterocyclic and polycyclic compounds in academic and industrial R&D.
• Adhesive & Coating Formulations: Incorporated into formulations to improve the performance and durability of high-end adhesives and coatings.

Basic Information

Item	Detail
Product Name	n-tert-Butylmaleimide
CAS No.	4144-22-3
Molecular Formula	C8H11NO2
Molecular Weight	153.18 g/mol
Synonyms	N-(tert-Butyl)maleimide; 1-(1,1-Dimethylethyl)-1H-pyrrole-2,5-dione; tert-Butylmaleimide; N-tert-Butylmaleimide; 2,5-Pyrrolidinedione, 1-(1,1-dimethylethyl)-; N-t-Butylmaleimide; Maleimide, N-tert-butyl-; 4144-22-3
EINECS	223-967-6

Quality Control

Our n-tert-Butylmaleimide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.