Description

1-Propionylimidazole is a versatile and reactive chemical building block, specifically an N-acylimidazole derivative. This compound is valued for its role as a highly effective acylating agent in organic synthesis, facilitating the introduction of the propionyl group under mild conditions. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients, intermediates, and fine chemicals.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing amide bonds and modifying heterocyclic compounds.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the propionyl moiety is required.
• Peptide Chemistry: Employed as an acylating agent in peptide coupling reactions to minimize racemization.
• Polymer Chemistry: Serves as a monomer or modifying agent in the creation of specialty polymers and functional materials.
• Bioconjugation: Useful for labeling biomolecules such as proteins and nucleic acids under controlled conditions.
• Organic Synthesis Research: A fundamental tool in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel molecular libraries.

Basic Information

Product Name	1-Propionylimidazole
CAS No.	4122-52-5
Molecular Formula	C6H8N2O
Molecular Weight	124.14 g/mol
Synonyms	1-Propionylimidazole; N-Propionylimidazole; Propionylimidazole; Imidazole, 1-propionyl-; 1H-Imidazole, 1-(1-oxopropyl)-; N-(1-Oxopropyl)imidazole; Propionic acid imidazolide
EINECS	223-925-6

Quality Control

Our 1-Propionylimidazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing specific results for purity (typically ≥97% by HPLC), appearance, and identity is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.