Description

Trimethylsilylketene is a highly reactive organosilicon reagent, specifically a silyl ketene, widely utilized in advanced organic synthesis. Its primary value lies in its ability to act as a versatile synthon for the efficient construction of complex molecules, including β-lactams and other heterocyclic compounds. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce ketene functionality under mild conditions.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for the synthesis of β-lactam antibiotics and other active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the research and production of novel herbicides, fungicides, and insecticides.
• Polymer & Material Science: Serves as a monomer or modifier for creating specialized silicone-based polymers and advanced materials.
• Organic Methodology Research: Employed in academic and industrial R&D for developing new cycloaddition and annulation reactions.
• Fine Chemical Production: Facilitates the synthesis of complex esters, amides, and carboxylic acid derivatives.
• Protecting Group Strategy: Can be used in multi-step synthesis to temporarily mask reactive functional groups.

Basic Information

Product Name	Trimethylsilylketene
CAS No.	4071-85-6
Molecular Formula	C6H12OSi
Molecular Weight	128.25 g/mol
Synonyms	Trimethylsilylketene; (Trimethylsilyl)ketene; Ketene, trimethylsilyl-; TMS-Ketene; Trimethylsilyl ethenone; 2-(Trimethylsilyl)ethenone; 1-(Trimethylsilyl)ethenone; EINECS 223-782-8
EINECS	223-782-8

Quality Control

Our Trimethylsilylketene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including Gas Chromatography (GC) and Nuclear Magnetic Resonance (NMR) spectroscopy, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to maintain product integrity. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.