Description

Nodakenin CAS NO 495-31-8 is a bioactive coumarin glycoside, a key phytochemical constituent derived from the roots of *Angelica* species such as *Angelica gigas* and *Angelica dahurica*. This compound is valued for its significant role in pharmaceutical research and development, particularly in the study of neuroprotective, anti-inflammatory, and anti-cancer mechanisms. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for manufacturers and research institutions focused on natural product-based therapeutics and nutraceuticals.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of herbal extracts and finished products in quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key starting material or intermediate in the synthesis of more complex therapeutic agents.
• Nutraceutical and Dietary Supplement Formulation: Incorporated into supplements targeting cognitive health, inflammation, and overall wellness.
• Biomedical Research: Employed in in vitro and in vivo studies to investigate its pharmacological activities, including neuroprotection and modulation of immune response.
• Cosmeceutical Development: Explored for potential skin-brightening and anti-aging properties in advanced cosmetic formulations.
• Traditional Medicine Standardization: Used to standardize extracts of traditional herbs like Korean Angelica root for consistent potency and efficacy.

Basic Information

Product Name	Nodakenin
CAS No.	495-31-8
Molecular Formula	C20H24O9
Molecular Weight	408.40 g/mol
Synonyms	Nodakenetin 7-O-glucoside; Columbianetin-β-D-glucopyranoside; 7-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-8-(2-methylbutyryl)coumarin; Nodakenetin glucoside; Angelica gigas Nakai Coumarin; Decursinol glucoside; (S)-7-((6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy)-8-((S)-2-methylbutanoyl)chromen-2-one
EINECS	Contact for details

Quality Control

Our Nodakenin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We offer material suitable for research and development, with grades available that meet the needs of pharmaceutical and nutraceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, NMR, and MS. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥95.0% - ≥99.0%
Loss on Drying	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.