Description

(S)-1,2,3,4-Tetrahydro-1-[(3-Hydroxy-4-Methoxyphenyl)Methyl]-6-Methoxy-2-Methylisoquinolin-7-Ol is a high-purity chiral isoquinoline alkaloid derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated pharmaceutical intermediate and a key building block for research into bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of potential therapeutic agents targeting neurological and cardiovascular systems.
• Research Chemical: Used in academic and industrial R&D for studying structure-activity relationships (SAR) of isoquinoline-based compounds.
• Asymmetric Synthesis: Serves as a valuable chiral scaffold or ligand in catalytic asymmetric transformations.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Biochemical Research: Investigated for its interaction with various enzymes and receptors due to its complex phenolic and alkaloid structure.
• Fine Chemical Synthesis: A building block for creating more complex, high-value specialty chemicals with specific optical activity.

Basic Information

Product Name	(S)-1,2,3,4-Tetrahydro-1-[(3-Hydroxy-4-Methoxyphenyl)Methyl]-6-Methoxy-2-Methylisoquinolin-7-Ol
CAS No.	485-19-8
Molecular Formula	C20H25NO4
Molecular Weight	343.42 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methyl-7-isoquinolinol; (S)-Reticuline; (S)-Reticulin; (S)-1-[(3-Hydroxy-4-methoxyphenyl)methyl]-1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinol; (S)-1,2,3,4-Tetrahydro-1-(4-hydroxy-3-methoxybenzyl)-6-methoxy-2-methyl-7-isoquinolinol; (S)-1-(4-Hydroxy-3-methoxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydro-7-isoquinolinol; (S)-Reticuline Base; (S)-Norreticuline
EINECS	207-614-7

Quality Control

Our (S)-1,2,3,4-Tetrahydro-1-[(3-Hydroxy-4-Methoxyphenyl)Methyl]-6-Methoxy-2-Methylisoquinolin-7-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, to ensure it meets stringent specifications for research and pharmaceutical use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage to maintain stability and purity. Keep container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.