Description

5,8-Dioxopsoralen is a specialized furanocoumarin derivative, a key intermediate and reference standard in organic synthesis and pharmaceutical research. This compound matters for its role as a critical building block in the development of novel bioactive molecules, particularly in photochemotherapy and medicinal chemistry. It is needed by research institutions, pharmaceutical development labs, and fine chemical manufacturers focused on creating new therapeutic agents, especially those exploring psoralen-related compounds for dermatological and oncological applications.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel psoralen analogs and other complex heterocyclic compounds for drug discovery.
• Photochemotherapy Research: Used as a reference standard and active component in academic and industrial research investigating PUVA (Psoralen + UVA) therapy mechanisms and new photodynamic agents.
• Medicinal Chemistry: Acts as a scaffold for structure-activity relationship (SAR) studies to develop new molecules with targeted biological activity.
• Biochemical Research: Employed in studies of enzyme inhibition, DNA intercalation, and other biochemical interactions due to its specific furanocoumarin structure.
• Analytical Reference Standard: Provides a high-purity benchmark for quality control and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical and chemical analysis.
• Fine Chemical Synthesis: Utilized in multi-step organic syntheses to construct more complex natural product derivatives and specialty chemicals.

Basic Information

Product Name	5,8-Dioxopsoralen
CAS No.	483-36-3
Molecular Formula	C₁₁H₆O₄
Molecular Weight	202.16 g/mol
Synonyms	5,8-Dihydroxypsoralen; 5,8-Dihydroxyfuro[3,2-g]chromen-7-one; Psoralen-5,8-dione; 5,8-Dihydroxy-7H-furo[3,2-g][1]benzopyran-7-one; Allopsoralen derivative; 5,8-Dioxo-7H-furo[3,2-g]chromen-7-one
EINECS	207-593-5

Quality Control

Our 5,8-Dioxopsoralen is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assay and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as identity, purity, and impurity profile. We support compliance with relevant ICH guidelines for impurities and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area away from heat sources and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.