Description

Aristolochic Acid B CAS NO 475-80-9 is a specific nitrophenanthrene carboxylic acid derivative, a key member of the aristolochic acid family. This compound is of significant interest in biochemical and pharmacological research due to its distinct structural and biological properties. It serves as a critical reference standard and research material for scientists in toxicology, natural product chemistry, and drug discovery, particularly in studies related to nephrotoxicity and carcinogenicity.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification and quantification of aristolochic acids in herbal medicines and botanical extracts to ensure safety and compliance.
• Toxicological Research: Essential for in-vitro and in-vivo studies investigating the mechanisms of nephrotoxicity, carcinogenicity, and mutagenicity associated with aristolochic acid exposure.
• Biochemical Assay Development: Employed in the development and validation of analytical methods, such as HPLC and LC-MS, for the detection of aristolochic acid contaminants.
• Natural Product Chemistry: Serves as a pure chemical entity for structural elucidation, metabolic pathway studies, and the synthesis of derivatives for biological evaluation.
• Quality Control in Herbal Industry: Used by manufacturers and testing laboratories to screen and control the levels of this compound in raw materials and finished products to meet regulatory standards.
• Academic Research: A vital tool for universities and research institutes studying plant toxins, DNA adduct formation, and the safety profile of traditional remedies.

Basic Information

Item	Detail
Product Name	Aristolochic Acid B
CAS No.	475-80-9
Molecular Formula	C16H9NO6
Molecular Weight	311.25 g/mol
Synonyms	8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid; Aristolochic acid II; Aristolochic acid B; AA-II; Aristolochic acid B (AAII); Isoaristolochic acid B; Nitrophenanthrene carboxylic acid derivative
EINECS	207-491-7

Quality Control

Our Aristolochic Acid B is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation via spectroscopic methods (IR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Our quality system is designed to meet the rigorous demands of analytical and pharmaceutical reference material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light). Keep the container sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.