Description

(5Alpha)-7,8-Didehydro-4,5-Epoxy-3-Hydroxy-17-Methylmorphinan-6-One is a high-purity synthetic opioid alkaloid of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate and reference standard for the synthesis and analytical characterization of more complex opioid derivatives. It is primarily utilized by research institutions, pharmaceutical manufacturers, and analytical laboratories engaged in neuropharmacology, medicinal chemistry, and forensic science. The material is supplied under stringent quality control to ensure consistency and reliability for sensitive applications.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthetic pathways for novel opioid analgesics and antagonist medications.
• Analytical Reference Standard: Used for method development, calibration, and quantification in High-Performance Liquid Chromatography (HPLC), Gas Chromatography-Mass Spectrometry (GC-MS), and other analytical techniques.
• Medicinal Chemistry Research: A vital compound for structure-activity relationship (SAR) studies aimed at developing new central nervous system (CNS) active agents with improved efficacy and safety profiles.
• Forensic Analysis: Employed as a certified reference material (CRM) for the accurate identification and confirmation of related substances in forensic toxicology.
• Biochemical Research: Used in studies investigating opioid receptor binding, signal transduction pathways, and the biochemical mechanisms of addiction and pain.
• Quality Control (QC) Testing: Acts as a system suitability standard and impurity marker in the quality control of bulk active pharmaceutical ingredients (APIs) and finished dosage forms.

Basic Information

Product Name	(5Alpha)-7,8-Didehydro-4,5-Epoxy-3-Hydroxy-17-Methylmorphinan-6-One
CAS No.	467-02-7
Molecular Formula	C₁₈H₂₁NO₄
Molecular Weight	315.36 g/mol
Synonyms	Oripavine; 6-O-Methylthebaine; 6-O-Methylthebaine (Oripavine); 6-Methoxythebaine; 3-Hydroxy-6-methoxy-17-methyl-4,5α-epoxy-7,8-didehydromorphinan; 4,5α-Epoxy-3-hydroxy-17-methyl-6-methoxy-7,8-didehydromorphinan; 6-Desoxycodeine Methyl Ether; NSC 29290
EINECS	Contact for details

Quality Control

Every batch of (5Alpha)-7,8-Didehydro-4,5-Epoxy-3-Hydroxy-17-Methylmorphinan-6-One is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC-MS, and NMR, to ensure identity, purity, and conformity to specified standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and batch-to-batch consistency for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.