Description

8β-Chloro-6,7-Didehydro-4,5α-Epoxy-3-Methoxy-17-Methylmorphinan is a high-purity, advanced pharmaceutical intermediate belonging to the morphinan class of compounds. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of specialized opioid receptor ligands and other pharmacologically active molecules. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers requiring precise and reliable building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the research and development of novel opioid analgesics and antagonists.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies targeting central nervous system (CNS) receptors.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Employed in studies investigating the binding affinity and functional activity at mu, kappa, and delta opioid receptors.
• Process Chemistry Development: Utilized in the scale-up and optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	8β-Chloro-6,7-Didehydro-4,5α-Epoxy-3-Methoxy-17-Methylmorphinan
CAS No.	466-95-5
Molecular Formula	C₁₉H₂₂ClNO₃
Molecular Weight	347.84 g/mol
Synonyms	8β-Chloro-6,7-didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan; 8β-Chloronaltrexone; 8β-Chloro-6,7-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan; 8β-Chloro-17-methylmorphinan-4,5-epoxy-3-methoxy-6,7-didehydro; 8β-Chloro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6,7-diene; 8β-Chloro-6,7-didehydro-4,5-epoxy-3-methoxy-N-methylmorphinan
EINECS	Contact for details

Quality Control

Our 8β-Chloro-6,7-Didehydro-4,5α-Epoxy-3-Methoxy-17-Methylmorphinan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.