Description

1-Chloro-4-Fluorobutane is a versatile halogenated alkane building block of significant importance in advanced organic synthesis. Its bifunctional nature, featuring both chloro and fluoro terminal groups, makes it a valuable intermediate for constructing more complex molecular architectures. This compound is primarily utilized by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated alkyl chains which can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and pesticides where the fluorobutane moiety contributes to product efficacy and environmental persistence profiles.
• Liquid Crystal & OLED Material Production: Acts as a starting material for synthesizing fluorinated components essential in electronic display technologies.
• Polymer Modification: Employed to introduce functional groups into polymer backbones, altering physical properties like solubility, thermal stability, and chemical resistance.
• Organic Synthesis Building Block: Utilized in nucleophilic substitution reactions, cyclizations, and as a linker in medicinal chemistry for probe and drug discovery.
• Solvent & Extraction Agent: Its specific properties can be leveraged in specialized solvent applications and extraction processes for sensitive compounds.

Basic Information

Product Name	1-Chloro-4-Fluorobutane
CAS No.	462-73-7
Molecular Formula	C4H8ClF
Molecular Weight	110.56 g/mol
Synonyms	4-Fluoro-1-chlorobutane; Butane, 1-chloro-4-fluoro-; 4-Fluorobutyl chloride; 1-Chloro-4-fluorobutane; γ-Fluorobutyl chloride; NSC 3773; FC-Butyl Chloride; 4-Fluorobutylchloride
EINECS	207-328-4

Quality Control

Our 1-Chloro-4-Fluorobutane is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including GC, NMR, and Karl Fischer titration to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	1.05 - 1.10 g/mL
Boiling Point	Approx. 105 - 110°C
Refractive Index (n20D)	1.410 - 1.415

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.