Description

1-Bromo-4-Fluorobutane is a versatile halogenated alkane building block of significant importance in advanced organic synthesis. Its bifunctional nature, featuring both a reactive bromine and a fluorine atom, makes it a critical intermediate for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries seeking to introduce fluorinated alkyl chains or create novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated side chains to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated organic compounds used in electronic displays and optoelectronic devices.
• Polymer Modification: Employed to introduce functional groups into polymer backbones, altering physical properties like solubility, thermal stability, and surface energy.
• Cross-coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form carbon-carbon bonds.
• Nucleophilic Substitution Substrate: The bromine atom is an excellent leaving group for reactions with a wide range of nucleophiles, enabling chain elongation and functional group interconversion.

Basic Information

Product Name	1-Bromo-4-Fluorobutane
CAS No.	462-72-6
Molecular Formula	C4H8BrF
Molecular Weight	155.01 g/mol
Synonyms	4-Fluorobutyl bromide; Butane, 1-bromo-4-fluoro-; 4-Fluoro-1-bromobutane; 1-Fluoro-4-bromobutane; 4-Fluorobutylbromide; F(CH2)4Br; γ-Fluoropropylbromomethane
EINECS	207-329-6

Quality Control

Our 1-Bromo-4-Fluorobutane is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for manufacturing, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat sources and incompatible materials. Due to its highly volatile nature, keep containers tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	1.35 - 1.45 g/mL
Refractive Index (n20D)	1.440 - 1.450

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.