Description

1-(3-Bromophenyl)-2,2,2-Trifluoroethanol is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a bromine substituent and a trifluoroethanol group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic motifs to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the introduction of fluorine and bromine atoms can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a precursor in the synthesis of fluorinated compounds for electronic applications, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Employed to introduce fluorinated side chains into polymers, improving material properties such as chemical resistance, thermal stability, and surface characteristics.
• Cross-Coupling Reactions: The bromophenyl moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck), enabling the construction of complex biaryl systems.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on novel fluorination methodologies and exploring structure-activity relationships (SAR).

Basic Information

Product Name	1-(3-Bromophenyl)-2,2,2-Trifluoroethanol
CAS No.	446-63-9
Molecular Formula	C8H6BrF3O
Molecular Weight	255.03 g/mol
Synonyms	3-Bromo-α,α,α-trifluorobenzeneethanol; (3-Bromophenyl)trifluoromethylcarbinol; 1-(3-Bromophenyl)-2,2,2-trifluoroethan-1-ol; 2,2,2-Trifluoro-1-(3-bromophenyl)ethanol; m-Bromo-α,α,α-trifluorobenzyl alcohol; 3-Bromo-α,α,α-trifluorobenzyl alcohol; 1-(3-Bromophenyl)-2,2,2-trifluoroethyl alcohol
EINECS	Contact for details

Quality Control

Our 1-(3-Bromophenyl)-2,2,2-Trifluoroethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤1.0%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.