Description

2-Amino-4-Trifluoromethyl-Thiazole-5-Carboxylic Acid Methyl Ester is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of a reactive amino group, a thiazole ring, and a trifluoromethyl moiety, enabling the construction of complex molecules with tailored properties. This compound is critically needed by R&D and production chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in antiviral, antibacterial, and anti-inflammatory research programs.
• Agrochemical Synthesis: Serves as a crucial precursor for creating advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiazole core.
• Material Science Research: Used in the synthesis of specialty chemicals, dyes, and functional materials where the trifluoromethyl group imparts unique stability and electronic characteristics.
• Custom Synthesis & Contract Manufacturing: An important starting material for custom synthesis projects requiring precise, high-purity heterocyclic compounds.

Basic Information

Product Name	2-Amino-4-Trifluoromethyl-Thiazole-5-Carboxylic Acid Methyl Ester
CAS No.	445-21-6
Molecular Formula	C6H5F3N2O2S
Molecular Weight	226.18 g/mol
Synonyms	Methyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate; 2-Amino-4-(trifluoromethyl)-5-thiazolecarboxylic acid methyl ester; 5-Thiazolecarboxylic acid, 2-amino-4-(trifluoromethyl)-, methyl ester; 4-(Trifluoromethyl)-2-amino-5-thiazolecarboxylic acid methyl ester; ATFMT-CME; 445-21-6
EINECS	Contact for details

Quality Control

Our production of 2-Amino-4-Trifluoromethyl-Thiazole-5-Carboxylic Acid Methyl Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required for pharmaceutical and agrochemical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.