Description

1,2-Bis(Trifluoromethyl)Benzene is a high-value fluorinated aromatic compound, serving as a critical building block in advanced chemical synthesis. Its unique structure, featuring two electron-withdrawing trifluoromethyl groups on the benzene ring, makes it an essential precursor for pharmaceuticals, agrochemicals, and specialty materials. This compound is primarily sought by R&D chemists and process engineers in the fine chemical, pharmaceutical, and advanced material manufacturing sectors.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the introduction of fluorine atoms improves efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a backbone for creating sophisticated ligands in transition metal catalysis and organocatalysis.
• Material Science: Employed in the synthesis of monomers for high-performance polymers, liquid crystals, and electronic materials.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, nucleophilic aromatic substitutions, and as a precursor for other complex fluorinated arenes.

Basic Information

Product Name	1,2-Bis(Trifluoromethyl)Benzene
CAS No.	433-95-4
Molecular Formula	C8H4F6
Molecular Weight	214.11 g/mol
Synonyms	o-Bis(trifluoromethyl)benzene; 1,2-Di(trifluoromethyl)benzene; Benzene, 1,2-bis(trifluoromethyl)-; α,α,α,α',α',α'-Hexafluoro-o-xylene; o-Xylene hexafluoride; o-(Trifluoromethyl)benzotrifluoride; Hexafluoro-o-xylene; NSC 9235
EINECS	207-099-4

Quality Control

Our 1,2-Bis(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure it meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and fluorides. The container must be kept tightly sealed to prevent moisture ingress and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (20°C)	~1.48 g/cm³
Boiling Point	~142-144 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.