Description

4-Iodo-1,1,2-Trifluorobut-1-Ene is a versatile fluorinated organic building block, valued for its unique combination of iodine and fluorine atoms which introduce distinct reactivity and physicochemical properties. This compound is essential for advanced synthetic chemistry, particularly in the development of novel pharmaceuticals, agrochemicals, and functional materials. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated active pharmaceutical ingredients (APIs), leveraging the iodine atom for cross-coupling reactions and fluorine for modulating bioavailability and metabolic stability.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, where the fluorine atoms enhance lipophilicity and environmental persistence.
• Material Science: Serves as a precursor for fluorinated polymers, liquid crystals, and organic electronic materials, contributing to desired thermal and chemical resistance properties.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic substitution reactions to introduce fluorinated vinyl or alkyl segments.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of polyfluorination and vinylic iodine on reaction mechanisms and physical properties in academic and industrial R&D settings.

Basic Information

Product Name	4-Iodo-1,1,2-Trifluorobut-1-Ene
CAS No.	401-52-5
Molecular Formula	C4H3F3I
Molecular Weight	251.97 g/mol
Synonyms	1,1,2-Trifluoro-4-iodobut-1-ene; 4-Iodo-1,1,2-trifluoro-1-butene; But-1-ene, 4-iodo-1,1,2-trifluoro-; 1-Butene, 4-iodo-1,1,2-trifluoro-; 4-Iodo-1,1,2-trifluorobutene; 401-52-5 (CAS RN)
EINECS	Contact for details

Quality Control

Our 4-Iodo-1,1,2-Trifluorobut-1-Ene is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality parameters. Our quality systems are designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept upright and sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.