Description

(S)-2-(tert-Butoxycarbonyl)-6-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity, chiral tetrahydroisoquinoline derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and bioactive compounds. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly those targeting neurological and cardiovascular systems.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the construction of focused libraries for high-throughput screening.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog for the development of novel peptide-like molecules with enhanced stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric transformations to introduce stereochemical complexity.
• Process Chemistry & Scale-Up: Used in the development and optimization of scalable synthetic routes for potential commercial APIs.

Basic Information

Product Name	(S)-2-(tert-Butoxycarbonyl)-6-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	398476-78-3
Molecular Formula	C15H19NO5
Molecular Weight	293.32 g/mol
Synonyms	(3S)-2-[(2-Methylpropan-2-yl)oxycarbonyl]-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (S)-Boc-6-hydroxy-Tic-OH; (S)-N-Boc-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Boc-6-OH-Tic-OH(S); 6-Hydroxy-N-Boc-(S)-Tic; (S)-2-(tert-Butoxycarbonyl)-6-hydroxy-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid
EINECS	Contact for details

Quality Control

Our (S)-2-(tert-Butoxycarbonyl)-6-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under dry, inert conditions for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.