Description

5(1H)-Indolizinone, Hexahydro-6-Hydroxy-, (6R,8As)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its complex fused bicyclic structure containing both indolizinone and hydroxyl functionalities makes it a valuable intermediate for constructing pharmacologically active molecules. This compound is primarily targeted at research and development organizations within the pharmaceutical and agrochemical sectors, where it is used to develop novel active ingredients and explore new chemical spaces.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and anti-infective targets.
• Agrochemical Research: Used in the development of novel, high-specificity pesticides and herbicides, leveraging its complex heterocyclic core.
• Asymmetric Synthesis: Acts as a sophisticated starting material or intermediate in catalytic asymmetric reactions to introduce molecular complexity.
• Medicinal Chemistry Libraries: Incorporated into compound libraries for high-throughput screening to identify new biological activity.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study enzyme function and biological pathways.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of complex target molecules.

Basic Information

Product Name	5(1H)-Indolizinone, Hexahydro-6-Hydroxy-, (6R,8As)-Rel- (9Ci)
CAS No.	398138-54-0
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	(6R,8aS)-Hexahydro-6-hydroxy-5(1H)-indolizinone; rel-(6R,8aS)-Hexahydro-6-hydroxy-1H-indolizin-5-one; Hexahydro-6-hydroxy-5(1H)-indolizinone, (6R,8aS)-rel-; 398138-54-0; (6R,8aS)-rel-Hexahydro-6-hydroxy-1H-indolizin-5-one; (6R,8aS)-rel-Octahydro-6-hydroxy-indolizin-5-one
EINECS	Contact for details

Quality Control

Our 5(1H)-Indolizinone, Hexahydro-6-Hydroxy-, (6R,8As)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and specific analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.