Description

5-Nitro-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is a high-purity, protected intermediate of significant value in advanced organic synthesis. This compound is specifically engineered to serve as a critical building block for the development of complex pharmaceutical molecules and fine chemicals. It is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key protected precursor in the synthesis of novel isoquinoline-based drug candidates, including potential kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging the nitro and heterocyclic functionalities.
• Organic Synthesis Building Block: The tert-butyl ester group provides excellent protection for the carboxylic acid, making it a versatile synthon for constructing complex molecular architectures in medicinal chemistry.
• Chemical Biology Probes: Employed in the creation of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Academic & Contract Research: Serves as a valuable reagent for universities and CROs (Contract Research Organizations) engaged in cutting-edge synthetic methodology and new chemical entity (NCE) discovery.

Basic Information

Product Name	5-Nitro-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester
CAS No.	397864-14-1
Molecular Formula	C14H16N2O4
Molecular Weight	276.29 g/mol
Synonyms	tert-Butyl 5-nitro-3,4-dihydro-1H-isoquinoline-2-carboxylate; 5-Nitro-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2-tert-Butoxycarbonyl-5-nitro-1,2,3,4-tetrahydroisoquinoline; 5-Nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 1,1-dimethylethyl ester; Boc-5-Nitro-Tic-OH tert-butyl ester; 397864-14-1
EINECS	Contact for details

Quality Control

Our 5-Nitro-3,4-Dihydro-1H-Isoquinoline-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), identity confirmation, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.