Description

2-Thiophenecarboxylic Acid, 5-Bromo-4-Fluoro-, Methyl Ester is a high-value, multi-functional heterocyclic building block designed for advanced chemical synthesis. This compound matters for its role as a critical intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and novel materials that require a substituted thiophene core.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the thiophene moiety contributes to biological activity.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials due to its conjugated system.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and other transformations to introduce complex, halogenated thiophene units into larger molecular architectures.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new chemical spaces in medicinal and synthetic chemistry.

Basic Information

Product Name	2-Thiophenecarboxylic Acid, 5-Bromo-4-Fluoro-, Methyl Ester
CAS No.	395664-59-2
Molecular Formula	C7H4BrFO2S
Molecular Weight	251.07 g/mol
Synonyms	Methyl 5-bromo-4-fluorothiophene-2-carboxylate; 5-Bromo-4-fluoro-2-thiophenecarboxylic acid methyl ester; 5-Bromo-4-fluorothiophene-2-carboxylic acid methyl ester; Methyl 5-bromo-4-fluorothiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 5-bromo-4-fluoro-, methyl ester; 5-Bromo-4-fluorothiophene-2-methyl carboxylate; Thiophene-2-carboxylic acid, 5-bromo-4-fluoro-, methyl ester
EINECS	Contact for details

Quality Control

Our 2-Thiophenecarboxylic Acid, 5-Bromo-4-Fluoro-, Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.