Description

3-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole-5-Carbonitrile is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and targeted therapy research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors seeking to develop new drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules, especially kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with therapeutic potential.
• Process Chemistry Development: Serves as a standard or reference material for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Bioconjugation & Probe Synthesis: The reactive bromo and nitrile functional groups make it suitable for creating labeled compounds or molecular probes for biochemical assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Product Name	3-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole-5-Carbonitrile
CAS No.	395101-69-6
Molecular Formula	C13H12BrN3O
Molecular Weight	306.16 g/mol
Synonyms	3-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-5-carbonitrile; 1H-Indazole-5-carbonitrile, 3-bromo-1-(tetrahydro-2H-pyran-2-yl)-; 3-Bromo-1-THP-indazole-5-carbonitrile; 3-Bromo-1-(2-tetrahydropyranyl)-1H-indazole-5-carbonitrile; 395101-69-6; THP-protected 3-bromoindazole-5-carbonitrile
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole-5-Carbonitrile is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and process development. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results from HPLC, NMR, and other relevant analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.