Description

3-(3-(Trifluoromethyl)Phenyl)-1H-Indazol-5-Amine CAS NO 395099-47-5 is a high-purity, advanced pharmaceutical intermediate characterized by its unique indazole core and trifluoromethylphenyl substituent. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for creating novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate its specific pharmacophore into new molecular entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and hit-to-lead optimization due to its privileged indazole scaffold.
• Kinase Inhibitor Development: Serves as a core structure for the design and synthesis of potent and selective kinase inhibitors.
• Agrochemical Active Ingredient Synthesis: Employed in the research and production of advanced crop protection agents.
• Fine Chemical Synthesis: Utilized as a specialized reagent for constructing complex, fluorinated heterocyclic compounds in custom synthesis projects.
• Biochemical Tool Compound: Acts as a reference standard or probe in biochemical and pharmacological assays.

Basic Information

Product Name	3-(3-(Trifluoromethyl)Phenyl)-1H-Indazol-5-Amine
CAS No.	395099-47-5
Molecular Formula	C14H10F3N3
Molecular Weight	277.25 g/mol
Synonyms	5-Amino-3-[3-(trifluoromethyl)phenyl]-1H-indazole; 3-(3-(Trifluoromethyl)phenyl)-1H-indazol-5-amine; 1H-Indazol-5-amine, 3-[3-(trifluoromethyl)phenyl]-; 395099-47-5; 3-(α,α,α-Trifluoro-m-tolyl)-1H-indazol-5-ylamine; 5-Amino-3-(3-trifluoromethylphenyl)indazole
EINECS	Contact for details

Quality Control

Our 3-(3-(Trifluoromethyl)Phenyl)-1H-Indazol-5-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with client specifications and current industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.