Description

(R)-2-(5-Bromo-4-(4-Chlorobenzyl)-7-Fluoro-1,2,3,4-Tetrahydrocyclopenta[B]Indol-3-Yl)Acetic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its complex, chiral molecular structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of oncology and central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers requiring a reliable and consistent supply of this sophisticated building block.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of potent, targeted small-molecule drugs.
• Oncology Research: Used in the development of novel kinase inhibitors and other anti-cancer compounds due to its specific bromo, chloro, and fluoro substituents.
• CNS Drug Discovery: Employed in medicinal chemistry programs targeting neurological and psychiatric conditions.
• Process Chemistry & Scale-Up: A critical material for process optimization and pilot-scale production of candidate drugs.
• Academic & Institutional Research: Utilized in universities and research institutes for studying structure-activity relationships (SAR) and novel synthetic pathways.
• Custom Synthesis: Acts as a starting point for the custom synthesis of more complex, proprietary molecules for client-specific projects.

Basic Information

Product Name	(R)-2-(5-Bromo-4-(4-Chlorobenzyl)-7-Fluoro-1,2,3,4-Tetrahydrocyclopenta[B]Indol-3-Yl)Acetic Acid
CAS No.	393509-05-2
Molecular Formula	C21H18BrClFNO2
Molecular Weight	474.73 g/mol
Synonyms	(3R)-2-[5-Bromo-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid; (R)-5-Bromo-4-(4-chlorobenzyl)-7-fluoro-1,2,3,4-tetrahydrocyclopenta[b]indole-3-acetic acid; 393509-05-2; UNII-8K3C5J4Z6P; 8K3C5J4Z6P; SCHEMBL218064; AKOS040759623; A-973
EINECS	Contact for details

Quality Control

Our production of (R)-2-(5-Bromo-4-(4-Chlorobenzyl)-7-Fluoro-1,2,3,4-Tetrahydrocyclopenta[B]Indol-3-Yl)Acetic Acid adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We maintain GMP-compliant documentation and can provide material to meet specific client requirements for chiral purity and residual solvent levels.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.