Description

6-Formyl-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester is a versatile and high-value indole derivative, serving as a critical protected intermediate in advanced organic synthesis. Its primary commercial value lies in enabling the efficient construction of complex pharmaceutical scaffolds, particularly for active pharmaceutical ingredients (APIs) and drug discovery candidates. This compound is essential for research and development chemists and process chemists in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of indole-based drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides that utilize the indole core structure.
• Organic Synthesis Reagent: Serves as a protected aldehyde-functionalized indole precursor for complex multi-step reactions, including palladium-catalyzed cross-couplings and nucleophilic additions.
• Material Science Research: Potential monomer or precursor for specialty polymers and advanced organic electronic materials.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom synthesis facilities for client-specific projects and library synthesis.

Basic Information

Product Name	6-Formyl-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	391668-75-0
Molecular Formula	C14H17NO3
Molecular Weight	247.29 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-2,3-dihydro-1H-indole-6-carboxaldehyde; 1-Boc-2,3-dihydroindole-6-carboxaldehyde; 6-Formyl-2,3-dihydro-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 6-formyl-2,3-dihydro-1H-indole-1-carboxylate; 1-Boc-6-formylindoline; 2,3-Dihydro-1H-indole-6-carboxaldehyde, 1-(1,1-dimethylethyl) 1-carboxylate; 6-Aldehyde-1-Boc-indoline
EINECS	Contact for details

Quality Control

Our 6-Formyl-2,3-Dihydro-Indole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot, supporting its use in cGMP and ISO-compliant environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.