Description

(R)-1-Amino-3-Methylbutylboronic Acid is a chiral, bifunctional organoboron compound that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a primary amine and a boronic acid functional group, makes it a versatile intermediate for constructing complex molecules with high stereochemical fidelity. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of novel therapeutics and advanced materials. Its utility lies in enabling efficient, selective chemical transformations that are fundamental to drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, enzyme inhibitors, and other bioactive molecules.
• Suzuki-Miyaura Cross-Coupling: Serves as a boronic acid coupling partner for the formation of carbon-carbon bonds in complex molecule assembly.
• Peptidomimetic Research: Used in the design and synthesis of peptide analogs and constrained peptides for drug development.
• Ligand Synthesis: Building block for creating novel chiral ligands and catalysts used in asymmetric synthesis.
• Bioconjugation: Facilitates the site-specific modification of biomolecules for diagnostic and therapeutic applications.
• Material Science: Precursor for boron-containing polymers and advanced organic frameworks with specialized properties.

Basic Information

Product Name	(R)-1-Amino-3-Methylbutylboronic Acid
CAS No.	389799-97-7
Molecular Formula	C5H14BNO2
Molecular Weight	131.00 g/mol
Synonyms	(R)-1-Amino-3-methylbutylboronic acid; (R)-3-Methyl-1-(aminomethyl)propylboronic acid; (R)-1-Amino-3-methylbutaneboronic acid; (R)-3-Methyl-1-aminobutylboronic acid; (R)-HomoVal(Bor)-OH; (R)-5-Amino-3-methylpentylboronic acid; B-(1-Amino-3-methylbutyl)boronic acid, (R)-; (R)-α-Aminoisoamylboronic acid
EINECS	Contact for details

Quality Control

Our (R)-1-Amino-3-Methylbutylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications in cGMP environments and research requiring the highest standards of chemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially air-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.