Description

Ethyl 3-[5-(Chlorosulfonyl)-2-Thienyl]-1,2,4-oxadiazole-5-carboxylate is a high-value, multifunctional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a reactive chlorosulfonyl group and a versatile oxadiazole-carboxylate ester moiety, enabling precise molecular construction. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and metabolic conditions.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its heterocyclic core for bioactivity.
• Material Science Research: Serves as a building block for creating functional polymers, liquid crystals, and organic electronic materials due to its conjugated thienyl-oxadiazole system.
• Chemical Biology Probe Development: Utilized in designing activity-based probes and molecular tags for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a sulfonamide or sulfonyl chloride functionality onto a complex heterocyclic scaffold.

Basic Information

Product Name	Ethyl 3-[5-(Chlorosulfonyl)-2-Thienyl]-1,2,4-oxadiazole-5-carboxylate
CAS No.	388088-70-8
Molecular Formula	C9H7ClN2O5S2
Molecular Weight	322.75 g/mol
Synonyms	Ethyl 3-(5-chlorosulfonylthiophen-2-yl)-1,2,4-oxadiazole-5-carboxylate; 5-(Chlorosulfonyl)-2-thiophenecarboxylic acid, 2-(5-ethoxycarbonyl-1,2,4-oxadiazol-3-yl) ester; 3-(5-Chlorosulfonyl-2-thienyl)-5-(ethoxycarbonyl)-1,2,4-oxadiazole; 1,2,4-Oxadiazole-5-carboxylic acid, 3-[5-(chlorosulfonyl)-2-thienyl]-, ethyl ester; CAS 388088-70-8; Thiophene-2-sulfonyl chloride, 5-(5-ethoxycarbonyl-1,2,4-oxadiazol-3-yl)-
EINECS	Contact for details

Quality Control

Our production of Ethyl 3-[5-(Chlorosulfonyl)-2-Thienyl]-1,2,4-oxadiazole-5-carboxylate adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with research-grade and custom synthesis specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.