Description

L-Aspartic Acid-n-Fmoc, β-o-tert- Butyl Ester (13C4,15N) is a high-purity, isotopically labeled derivative of aspartic acid, specifically engineered for advanced research and development. This compound is a critical building block for the synthesis of peptides and proteins with stable isotope labels, enabling precise metabolic and structural studies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs specializing in proteomics, metabolic pathway analysis, and drug discovery.

Application

• Stable Isotope Labeling in Proteomics: Used as a labeled precursor for mass spectrometry-based protein quantification and turnover studies.
• Metabolic Pathway Tracing: Enables the detailed tracking and analysis of amino acid metabolism in biological systems using NMR or LC-MS.
• Synthesis of Labeled Peptides & Proteins: Serves as a key protected and labeled amino acid derivative in solid-phase peptide synthesis (SPPS).
• Biomolecular NMR Spectroscopy: Provides site-specific 13C and 15N labels for structural and dynamic studies of proteins and peptides.
• Drug Discovery & Development: Facilitates pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies of peptide-based drug candidates.
• Standards for Analytical Chemistry: Used as an internal standard for the accurate quantification of aspartic acid or related peptides in complex matrices.

Basic Information

Product Name	L-Aspartic Acid-n-Fmoc, β-o-tert- Butyl Ester (13C4,15N)
CAS No.	387867-74-5
Molecular Formula	C23H2213C415NNO6
Molecular Weight	~438.4 g/mol (for labeled form)
Synonyms	Fmoc-Asp(OtBu)-OH (13C4, 15N); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid 4-tert-butyl ester (13C4, 15N); Fmoc-L-Asp(OtBu)-OH (13C4, 15N); (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-tert-butoxy-4-oxobutanoic-1,2,3,4-13C4,2-15N acid; Isotopically labeled Fmoc-Asp(OtBu)-OH; Stable isotope-labeled Fmoc-protected aspartic acid derivative
EINECS	Contact for details

Quality Control

Our L-Aspartic Acid-n-Fmoc, β-o-tert- Butyl Ester (13C4,15N) is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for critical research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity confirmation. We adhere to cGMP guidelines for advanced intermediates and provide traceable documentation for regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Isotopic Enrichment (15N)	≥ 99 atom % 15N
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.