Description

2-Cyclohexyl-3-(4-Methoxyphenyl)-1-Oxo-1,2,3,4-Tetrahydro-4-Isoquinolinecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate designed for critical synthesis pathways. This compound is valued for its role as a key building block in the research and development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• API Development: Used in the process development and scale-up of new chemical entities (NCEs) requiring a tetrahydroisoquinoline core structure.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	2-Cyclohexyl-3-(4-Methoxyphenyl)-1-Oxo-1,2,3,4-Tetrahydro-4-Isoquinolinecarboxylic Acid
CAS No.	385383-39-1
Molecular Formula	C23H25NO4
Molecular Weight	379.45 g/mol
Synonyms	4-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-cyclohexyl-3-(4-methoxyphenyl)-1-oxo-; 2-Cyclohexyl-3-(4-methoxyphenyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid; 1-Oxo-2-cyclohexyl-3-(4-methoxyphenyl)-1,2,3,4-tetrahydro-4-isoquinolinecarboxylic acid; Tetrahydroisoquinoline carboxylic acid derivative; CAS 385383-39-1
EINECS	Contact for details

Quality Control

Our 2-Cyclohexyl-3-(4-Methoxyphenyl)-1-Oxo-1,2,3,4-Tetrahydro-4-Isoquinolinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP requirements. Our quality commitment supports seamless integration into sensitive pharmaceutical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product should be kept under an inert atmosphere if long-term storage is required to prevent potential degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.