Description

1,4-Thiazepine-3-Carboxylicacid,5-Amino-2,3,6,7-Tetrahydro-,Ethylester,(3R)-(9Ci) is a high-purity, chiral organic compound with a complex heterocyclic structure, serving as a critical advanced pharmaceutical intermediate. Its value lies in its role as a sophisticated building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. This product is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology industries, where it is used to construct complex molecular architectures for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and commercial synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with targeted biological activity.
• Process Chemistry & Scale-Up: Serves as a defined starting material or intermediate in the development of robust, scalable synthetic routes for API manufacturing under GMP conditions.
• Asymmetric Synthesis: Utilized in chiral pool synthesis or as a template for constructing molecules with specific three-dimensional configurations required for drug efficacy.
• Bioconjugation & Probe Development: Potential use in creating labeled compounds or molecular probes for biochemical and pharmacological research due to its functionalizable amine and ester groups.

Basic Information

Product Name	1,4-Thiazepine-3-Carboxylicacid,5-Amino-2,3,6,7-Tetrahydro-,Ethylester,(3R)-(9Ci)
CAS No.	384330-29-4
Molecular Formula	C9H14N2O2S
Molecular Weight	214.28 g/mol
Synonyms	(3R)-5-Amino-2,3,6,7-tetrahydro-1,4-thiazepine-3-carboxylic acid ethyl ester; Ethyl (3R)-5-amino-2,3,6,7-tetrahydro-1,4-thiazepine-3-carboxylate; (R)-5-Amino-2,3,6,7-tetrahydro-1,4-thiazepine-3-carboxylic acid ethyl ester; 1,4-Thiazepine-3-carboxylic acid, 5-amino-2,3,6,7-tetrahydro-, ethyl ester, (3R)-; 384330-29-4; (R)-Ethyl 5-amino-2,3,6,7-tetrahydro-1,4-thiazepine-3-carboxylate; 5-Amino-2,3,6,7-tetrahydro-1,4-thiazepine-3-carboxylic acid ethyl ester (R-enantiomer)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity suitable for pharmaceutical research. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as chiral purity, chemical purity, and impurity profiles. Quality is verified through modern analytical techniques including HPLC, GC, and NMR spectroscopy. While produced under controlled conditions, this product is typically offered as a research-grade chemical; specifications for GMP-grade material are available upon request and can be developed to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.