Description

4-Methoxytrityl Mercaptan is a specialized organosulfur compound featuring a methoxy-substituted trityl protecting group. This compound is of significant value in synthetic organic chemistry, particularly for the protection of thiol groups during complex multi-step synthesis. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the production of peptides, oligonucleotides, and other sensitive bioactive molecules where selective protection and deprotection strategies are critical.

Application

• Thiol Protection in Peptide Synthesis: Serves as a key protecting group for cysteine residues, preventing unwanted disulfide bond formation or side reactions during solid-phase or solution-phase peptide synthesis.
• Oligonucleotide and Nucleoside Chemistry: Used in the synthesis and modification of oligonucleotides, protecting sulfur-containing nucleobases or backbone linkages to ensure correct assembly and purity.
• Intermediate for Pharmaceutical Actives: Acts as a crucial building block in the multi-step synthesis of drug candidates, especially those containing critical thiol or disulfide functionalities.
• Material Science Research: Employed in the development of functionalized polymers, dendrimers, or surface coatings where controlled introduction of thiol groups is required.
• Bioconjugation and Probe Development: Useful for creating labeled biomolecules or chemical probes, where the protected thiol can be later deprotected for site-specific conjugation.

Basic Information

Product Name	4-Methoxytrityl Mercaptan
CAS No.	383401-03-4
Molecular Formula	C20H18OS
Molecular Weight	306.42 g/mol
Synonyms	MMTr-SH; (4-Methoxyphenyl)diphenylmethyl mercaptan; 4-Monomethoxytritylthiol; 4-Methoxytrityl Thiol; 4-MMT-SH; 1-[(4-Methoxyphenyl)diphenylmethyl]thiol; p-Methoxytrityl Mercaptan
EINECS	Contact for details

Quality Control

Our 4-Methoxytrityl Mercaptan is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label. Due to its sensitivity to oxidation, the container should be purged with inert gas after each opening to maintain product integrity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.