Description

Cyclohexanecarboxylic Acid, 2-[(2-Thienylcarbonyl)Amino]-, (1R,2R)-Rel- (9Ci) is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced organic synthesis. Its core value lies in providing a rigid, functionalized cyclohexane scaffold with precise stereochemistry, which is critical for constructing complex molecules with defined biological activity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and for use in process chemistry and method development.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and other therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where its specific stereochemistry can influence biological activity and environmental selectivity.
• Asymmetric Synthesis Catalyst/ Ligand Precursor: Serves as a precursor for chiral ligands or organocatalysts used in enantioselective transformations to produce other high-value chiral compounds.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in laboratories that synthesize or analyze related compounds.
• Academic & Process R&D: Utilized in university and industrial R&D settings for studying structure-activity relationships (SAR) and for scaling up synthetic routes in process chemistry.
• Fine Chemical Synthesis: Incorporated into the production of complex fine chemicals and specialty materials that require a defined stereochemical center.

Basic Information

Item	Details
Product Name	Cyclohexanecarboxylic Acid, 2-[(2-Thienylcarbonyl)Amino]-, (1R,2R)-Rel- (9Ci)
CAS No.	381241-68-5
Molecular Formula	C13H17NO3S
Molecular Weight	267.34 g/mol
Synonyms	(1R,2R)-2-[(Thiophene-2-carbonyl)amino]cyclohexane-1-carboxylic acid; rel-(1R,2R)-2-[(2-Thienylcarbonyl)amino]cyclohexanecarboxylic acid; (1R,2R)-2-(2-Thiophenecarboxamido)cyclohexanecarboxylic acid; 2-[(2-Thienylcarbonyl)amino]cyclohexanecarboxylic acid, (1R,2R)-rel-; (1R,2R)-rel-2-[(Thiophene-2-carbonyl)amino]cyclohexanecarboxylic acid; Chiral Cyclohexane Thiophene Amide Acid; 381241-68-5
EINECS	Contact for details

Quality Control

Our production of Cyclohexanecarboxylic Acid, 2-[(2-Thienylcarbonyl)Amino]-, (1R,2R)-Rel- (9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, identity confirmation by IR and NMR, and quantification of related substances. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (1R,2R)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.